DAEJEON, April 15 (Korea Bizwire) — A newly developed bone-replica chip will be able to verify the effects of new drugs for the treatment of osteoporosis without engaging in reckless animal experiments.
A research team from the Korea Basic Science Institute said Thursday it has developed a chip that embodies the various structural and biological features of human bone.
The extracellular matrix that fills in the gap between cells has been mixed with hydrogel, a collagen substance that uses water as a dispersion medium and bone cells to optimize biocompatibility and the unique ability of bone cells for growth and differentiation.
The bone cells have been placed horizontally to mimic the actual structure of the bone.
These replica chips can be used with a cell-based screening device to produce high-speed, high-resolution optical images.
The issue of excessive human labor and time needed to interpret large amounts of image data has been solved by introducing dedicated artificial intelligence (AI) technology.
The replica chip applied with an osteoporosis drug has been put up for high-speed photography to capture the movement of the beta-catenin cell’s nucleus, which controls the proliferation and differentiation of cell DNA, with which the AI system has estimated the drug’s effectiveness with 99.5 percent accuracy.
Kevin Lee (firstname.lastname@example.org)